Methadone detoxification of tramadol dependence
Leo RJ, Narendran R, DeGuiseppe B
Department of Psychiatry,
School of Medicine and Biomedical Sciences,
State University of New York at Buffalo,
Erie County Medical Center,
462 Grider Street,
14215, Buffalo, NY, USA.
J Subst Abuse Treat 2000 Oct; 19(3):297-


Tramadol hydrochloride is a centrally acting analgesic with a partial affinity for the opiate receptor (mu), having an analgesic potency estimated to be one tenth that of morphine. While preclinical investigations suggested that abuse liability associated with tramadol use is low, there are increasing numbers of cases reported to the U.S. Food and Drug Administration of abuse, dependence, and withdrawal associated with tramadol use. A case of a patient with tramadol dependence requiring detoxification with methadone is presented. Acute management of significant tramadol dependence has not yet been reported in the literature. Long-term treatment issues are also discussed.
Tramadol: dosage
Immune response
Abstinence syndrome
Tramadol and analgesia
Tramadol and acute pain
Tramadol versus morphine
Tramadol versus oxycodone
Official prescribing indications
Tramadol as an antidepressant
Tramadol: risk/benefit analysis
Tramadol, morphine and the stomach
Pharmacokinetics and pharmacodynamics
Tramadol, depression and Parkinson's disease

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