Insights into mu opioid pharmacology the role
of mu opioid receptor subtypes

by
Pasternak GW.
Laboratory of Molecular Neuropharmacology,
Memorial Sloan-Kettering Cancer Center,
New York, NY 10021, USA.
Life Sci2001;68(19-20):2213-9


ABSTRACT

Although mu opioids share many pharmacological characteristics, they also reveal many differences. Many approaches over the years have suggested the existence of multiple mu opioid receptors. The unique selectivities of naloxonazine, for example, provided a way of distinguishing mu, from mu2 actions. Studies of morphine-6beta-gluruconide suggested that its actions involved yet another mu opioid receptor subtype. The cloning of a mu opioid receptor, MOR-1, provided a way of exploring this possibility at the molecular level. Recent studies have now identified a number of splice variants of this gene that appear to be important in the production of mu opioid analgesia.
Mu
Pain
Heroin
SOD mu
The Pleasures of Opium
Breathing, mu1 and mu2
Mu opioid receptor subtypes
Genes, pharmacology and mu
Mice without mu don't miss their moms


Refs
and further reading

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The Abolitionist Project
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Critique of Huxley's Brave New World

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