Opioid receptors and acetaminophen (paracetamol)
by
Raffa RB, Walker EA, Sterious SN.
Department of Pharmaceutical Sciences,
Temple University School of Pharmacy,
3307 North Broad Street,
Philadelphia, PA 19140, USA.
Eur J Pharmacol. 2004 Oct 25;503(1-3):209-210


ABSTRACT

We report that the acetaminophen (paracetamol)-induced spinal (intrathecal, i.t.)/supraspinal (intracerebroventricular, i.c.v.) site/site antinociceptive 'self-synergy' in mice is attenuated by the opioid receptor subtype selective antagonists beta-funaltrexamine hydrochloride (beta-FNA; μ), naltrindole (delta), and nor-binaltorphine hydrochloride (nor-BNI; kappa). These findings further implicate endogenous opioids (viz., endorphins, enkephalins, and dynorphins) and their pathways as contributors to the central antinociceptive action of acetaminophen.
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