Kappa-opioid receptor blockade with nor-binaltorphimine modulates cocaine self-administration in drug-naive rats
by
Kuzmin AV, Gerrits MA, Van Ree JM
Laboratory of Pharmacology of Narcotics,
Pavlov Medical University,
St.-Petersburg, Russian Federation.
Eur J Pharmacol 1998 Oct 9; 358(3):197-202


ABSTRACT

The modulation of the reinforcing effects of cocaine by the kappa-opioid receptor antagonist, nor-binaltorphimine was studied by using the initiation of intravenous self-administration in drug-naive Wistar rats. Treatment with nor-binaltorphimine (3.0 mg/kg s.c.) 48 h before the start of the first of five daily self-administration sessions significantly decreased the intake of cocaine when offered in a threshold unit dose (30 micrograms per infusion), but had no effect on cocaine intake when it was offered in a higher unit dose (60 micrograms per infusion). It is concluded that blockade of the kappa-opioid receptor by nor-binaltorphimine may produce a rightward shift of the unit dose-response relationship of cocaine reward, thus decreasing the sensitivity to cocaine reward. These data suggest an involvement of endogenous kappa-opioid systems in the mechanisms underlying the initiation of cocaine self-administration behaviour.
Pain
JDTIc
Enadoline
Tramadol
Tolerance
Pentazocine
Endomorphins
Buprenorphine
Dihydroetorphine
Receptor subtypes
Norbinaltorphimine
Fentanyl and ketamine
Kappa upregulation and addiction
Kappa-opioid receptor antagonism
The kappa A agonist salvinorin A induces depression
Kappa opioid antagonists as antidepressants : norbinaltorphimine
The kappa receptor antagonist norbinaltorphimine as an antidepressant
JDTic: an antidepressant, anxiolytic kappa-selective opioid receptor antagonist


Refs
and further reading

HOME
HedWeb
Nootropics
Cocaine.org
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family